5 South Carolina Luxury Retreats from Lake Keowee to Myrtle Beach

Along the water’s edge in Ridge Top at The Cliffs at Keowee Falls, this custom Resort Custom Homes residence looks out over Falls Creek cove with long-water views and the steady sound of the waterfall. Douglas-fir siding, natural stone, and a synthetic cedar-style roof set a warm, grounded exterior. Inside, a great room with 22-foot vaulted ceilings, twin stone fireplaces, and disappearing sliders flows to a lakeside flagstone porch. The chef’s kitchen is outfitted with a Wolf gas 6-burner range and double ovens, paneled double Sub-Zero, two dishwashers, an oversized island with sink, and a walk-in pantry with ice maker. The main level includes a lake-view primary suite with spa bath, an additional ensuite, and a newly added sunroom with fireplace. Below, a fireside lounge, full bar, media room, screened porch, fire pit patio, and infinity-edge spa invite evenings that linger.

Along the water’s edge on one of Lake Keowee’s sought-after point lots, 117 Misty Water Loop pairs 288 feet of riprapped shoreline with open-water views stretching to the distant Blue Ridge Mountains. Double doors introduce a residence shaped by lodge-inspired scale and European countryside charm, with stone turrets, warm wood elements, and walls of glass set against manicured landscaping. A dramatic great room centers the main level with a soaring stone fireplace and exposed beams. The recently renovated kitchen shines with quartzite countertops, a six-burner Thermador gas cooktop, KitchenAid double oven and refrigerator, wine fridge, walk-in pantry, and an island with prep sink, alongside a dining nook, breakfast bar, and dedicated study. Downstairs, 12-foot ceilings frame a rec room with wet bar, wine cellar, and guest spaces, while Trex decking, a screened porch with fireplace, and an Ipe dock invite days paced by the lake.

Steps from the shoreline in Arcadian Shores, “Regal Palms” frames beachside living with a sense of ceremony and ease. A grand entrance sets the tone with stained glass doors, a crystal chandelier, and a foyer that flows past a library and formal dining. At the heart of the home, an updated kitchen is paired with a wet bar and a fireplace—designed for long, unhurried evenings. The sunroom overlooks a saltwater pool and hot tub, edged by artificial turf and complemented by a Tiki bar with kitchenette for effortless outdoor hosting. The master suite offers a luxurious bath, sauna, and walk-in closet, while additional bedrooms feature private baths. An elevator connects the floors, and exterior details include a landscaped driveway, multiple garages, plus a generator and backup system for added peace of mind.

Beyond a gated entrance in Holly Hill, SC, an oak-lined drive unfolds across 46 acres spanning two parcels, with fenced pastures and roughly 30–35 acres of woods suited to hunting. The property is arranged as a true working homestead with three separate residences and extensive outbuildings designed for animals, hobbies, and recreation. A 2019 Morton barndominium serves as the primary home, offering 3 bedrooms and 3 baths alongside an attached metal garage—complete with a 10,000-pound lift, six oversized bay doors, and dedicated dog quarters. A second 2019 home mirrors the flexibility with 3 bedrooms and 3 baths, an attached metal garage, and dog kennels. Completing the trio is a 2024 mobile home with 3 bedrooms, 2 baths, and a fenced backyard for pets. Despite the privacy, Charleston, Columbia, and Orangeburg remain within reach.

Along the water’s edge on Lake Keowee, this waterfront villa pairs long-range lake vistas with layered views of the Blue Ridge Mountains, just minutes from the heart of Seneca. Set on approximately .62 acres with more than 140 feet of shoreline, it includes a covered dock with lift and a gentle approach to the water. Inside, a dramatic wall of glass pulls the landscape into daily life, while wide-plank heart pine floors and hand-hewn ceiling beams bring warmth and craft to the main living areas. The Grand Room invites gathering, and the kitchen and keeping room center around a substantial table, anchored by a Lacanche range, Sub-Zero refrigeration, and custom cabinetry. A bedroom tower offers three separate suites, plus a primary retreat with a spa-inspired bath and secluded sitting area. Glass-enclosed loggia, lofted office, wine cellar, and flagstone terraces—with an outdoor kitchen and brick pizza oven—extend the home’s rhythm from sunrise to starlight.